2026
- Quantitative Systems Pharmacology (QSP): Bridging Biology and Mechanism with Clinical Drug Development DecisionsWang W, Ratushny AV, Chang S, Cheng Y, Gong JQX, Gulati A, Hansson E, Kulesza A, Reali F, Sandefur C, Schmidt BJ, Singh FA, Susilo ME, Zaph S, Shtylla B. Journal of Clinical Pharmacology 66(9):e70289.
DOI · PubMed
- Association between plasma glucosylsphingosine levels and dyskinesia burden in GBA1-related Parkinson's diseaseMarano M, Zizzo C, Cavallieri F, Avenali M, Schirinzi T, Monfrini E, Spagnolo F, De Micco R, Ramat S, Malaguti MC, Reali F, et al. Neurobiology of Disease 219:107271.
DOI · PubMed
2025
- Transforming Pediatric Rare Disease Drug Development: Enhancing Clinical Trials and Regulatory Evidence With Virtual PatientsSips F, Virgolin M, Pasculli G, Reali F, Paris A, Janus A, Godfrin Y, Röshammar D, Marchetti L, Knöchel J. CPT: Pharmacometrics & Systems Pharmacology 14(11):1739–1742.
DOI · PubMed
- A mechanistic model of pure and lipidic α-synuclein aggregation for advancing Parkinson's therapiesRighetti E, Marchetti L, Domenici E, Reali F. Communications Chemistry 8:186.
DOI · PubMed
- stormTB: a web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatmentsVisintainer R, Fochesato A, Boaretti D, Giampiccolo S, Watson S, Levi M, Reali F, Marchetti L. Frontiers in Pharmacology 15:1462193.
DOI · PubMed
2024
- Robust parameter estimation and identifiability analysis with hybrid neural ordinary differential equations in computational biologyGiampiccolo S, Reali F, Fochesato A, Iacca G, Marchetti L. npj Systems Biology and Applications 10:139.
DOI · PubMed
2023
- A minimal PBPK model to accelerate preclinical development of drugs against tuberculosisReali F*, Fochesato A*, Kaddi C, Visintainer R, Watson S, Levi M, Dartois V, Azer K, Marchetti L. Frontiers in Pharmacology 14:1272091. *Equal contribution.
DOI · PubMed
- Editorial: Use of quantitative systems pharmacology pipelines to bridge in vitro and in vivo results in drug discoveryReali F, Csikász-Nagy A, Selvaggio G. Frontiers in Systems Biology 3:1291610.
DOI
2022
- Mechanistic models of α-synuclein homeostasis for Parkinson's disease: A blueprint for therapeutic interventionRighetti E, Antonello A, Marchetti L, Domenici E, Reali F. Frontiers in Applied Mathematics and Statistics 8:1060489.
DOI
2021
- QSPcc reduces bottlenecks in computational model simulationsTomasoni D, Paris A, Giampiccolo S, Reali F, Simoni G, Marchetti L, Kaddi C, Neves-Zaph S, Priami C, Azer K, Lombardo R. Communications Biology 4:1022.
DOI · PubMed
- A robust computational pipeline for model-based and data-driven phenotype clusteringSimoni G, Kaddi C, Tao M, Reali F, Tomasoni D, Priami C, Azer K, Neves-Zaph S, Marchetti L. Bioinformatics 37(9):1269–1277.
DOI
- A Retrospective Analysis of the COVID-19 Pandemic Evolution in ItalyFochesato A, Simoni G, Reali F, Giordano G, Domenici E, Marchetti L. Biology 10(4):311.
DOI
2020
- A Quantitative Systems Pharmacology Model of Gaucher Disease Type 1 Provides Mechanistic Insight Into the Response to Substrate Reduction Therapy With EliglustatAbrams R, Kaddi C, Tao M, Leiser RJ, Simoni G, Reali F, Tolsma J, Jasper P, van Rijn Z, Li J, Niesner B, Barrett JS, Peterschmitt MJ, Marchetti L, Azer K, Neves-Zaph S. CPT: Pharmacometrics & Systems Pharmacology 9(7):374–383.
DOI · PubMed
2019
- Stochastic simulation algorithms for computational systems biology: Exact, approximate, and hybrid methodsSimoni G, Reali F, Priami C, Marchetti L. WIREs Systems Biology and Medicine 11(6):e1459.
DOI · PubMed
2018
- Incorporating extrinsic noise into the stochastic simulation of biochemical reactions: A comparison of approachesVo Hong T, Marchetti L, Reali F, Priami C. The Journal of Chemical Physics 148(6):064111.
DOI
2017
- Optimization algorithms for computational systems biologyReali F, Priami C, Marchetti L. Frontiers in Applied Mathematics and Statistics 3:6.
DOI
- Mechanistic interplay between ceramide and insulin resistanceReali F*, Morine MJ*, Kahramanoğulları O*, Raichur S, Schneider HS, Crowther D, Priami C. Scientific Reports 7:41231. *Equal contribution.
DOI
2016
- A Novel Insulin/Glucose Model after a Mixed-Meal Test in Patients with Type 1 Diabetes on Insulin Pump TherapyMarchetti L*, Reali F*, Dauriz M, Brangani C, Boselli L, Ceradini G, Bonora E, Bonadonna RC, Priami C. Scientific Reports 6:36029. *Equal contribution.
DOI
Conference proceedings / abstracts
- Digital Twins and Virtual Populations: Applications in Quantitative Systems PharmacologyReali F, Paris A, Giampiccolo S, Righetti E, Marchetti L. BUILD-IT 2023 Workshop — BUILding a Digital Twin: requirements, methods, and applications, CNR-INM, Rome, 2023. Book of Abstracts, ISBN 978-88-7617-056-0.
- An Extended Dynamical Model of α-Synuclein MetabolismReali F, Simoni G, Domenici E, Marchetti L. Proceedings of the 11th International Conference Dynamical Systems Applied to Biology and Natural Sciences, Trento, 2020, pp. 151–152. ISBN 978-989-98750-7-4.
- Integrated quantitative systems pharmacology (QSP) model of lysosomal diseases provides an innovative computational platform to support research and therapeutic development for the sphingolipidosesKaddi C, Reali F, Marchetti L, et al. Molecular Genetics and Metabolism 123(2), WORLD Symposium 2018.
DOI